Molecular Biology of Brucella Pathogenicity |
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Principal investigator:
Dr. Juan M. García-Lobo, Full Professor
Other personnel:
web page:
http://grupos.unican.es/micro/
Research lines:
o Brucella virulence factors (and their regulation).
o Comparative genomics of the genus Brucella
Funding:
Regulación de la virulencia de Brucella abortus mediada por Hfq
Ref: BFU2011-25658
PI: Felix J. Sangari García
2012 - 2014
Relevant publications (last 10 years):
AUTORES: Amélie Dricot, Jean-François Rual, Philippe Lamesch, Nicolas Bertin, Denis Dupuy, Tong Hao, Christophe Lambert, Régis Hallez, Jean-Marc Delroisse, Jean Vandenhaute, Ignacio Lopez-Goñi, Ignacio Moriyon, Juan M. Garcia-Lobo, Félix J. Sangari, Alastair P. MacMillan, Sally J. Cutler, Adrian M. Whatmore, Stephanie Bozak, Reynaldo Sequerra, Lynn Doucette-Stamm, Marc Vidal, David E. Hill, Jean-Jacques Letesson, and Xavier De Bolle.
TITULO: Generation of the Brucella melitensis ORFEOME, version 1.1.
REVISTA: Genome research. 14:2001-2006, 2004
AUTORES: Alain Ocampo, Jesús Agüero, and Juan M García Lobo.
TITULO: Development of a new PCR assay to identify Brucella abortus biovars 5, 6 and 9 and the new subgroup 3b of biovar 3.
REVISTA: Veterinary Microbiology. 110:41-51. 2005.
AUTORES: de Paz HD, Sangari FJ, Bolland S, Garcia-Lobo JM, Dehio C, de la Cruz F, Llosa M TITULO: Functional interactions between type IV secretion systems involved in DNA transfer and virulence.
REVISTA: Microbiology. 2005 Nov;151(Pt 11):3505-16.
AUTORES :de la Prieta M.C., Seoane, A., Francia M.V., and J.M. García Lobo
TITULO: Characterization of defective ß-lactamase genes in Yersinia enterocolitica
REVISTA: J. Antimicrob. Chemother. 58:661-664. 2006.
AUTORES : F.J. Sangari, Seoane, A., Rodríguez M.C., Agüero J. and J.M. García Lobo
TITULO: Characterization of the urease operon of Brucella abortus, and assessment of its role in the virulence of the bacteria.
REVISTA/LIBRO: Infection and Immunity 75:774-780. 2007
AUTORES: Alain Ocampo-Sosa, and Juan M García Lobo.
TITULO: Demonstration of IS711 transposition in Brucella ovis and Brucella pinnipedialis. REVISTA/LIBRO: BMC Microbiol. 2008 Jan 24;8:17.
AUTORES: Tsolis RM, Seshadri R, Santos RL, Sangari FJ, Lobo JM, de Jong MF, Ren Q, Myers G, Brinkac LM, Nelson WC, Deboy RT, Angiuoli S, Khouri H, Dimitrov G, Robinson JR, Mulligan S, Walker RL, Elzer PE, Hassan KA, Paulsen IT.
TITULO: Genome degradation in Brucella ovis corresponds with narrowing of its host range and tissue tropism.
REVISTA/LIBRO: PLoS ONE. 2009;4(5):e5519.
AUTORES: Viadas C, Rodríguez MC, García-Lobo JM, Sangari FJ, López-Goñi I.
TITULO: Construction and evaluation of an ORFeome-based Brucella whole-genome DNA microarray.
REVISTA/LIBRO: Microb Pathog. 47:189-195. 2009.
AUTORES: Sangari FJ, Pérez-Gil J, Carretero-Paulet L, García-Lobo JM, Rodríguez-Concepción M.
TÍTULO: A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria.
REVISTA: Proc Natl Acad Sci U S A. 107(32):14081-6. 2010
AUTORES: José Luis Lavín, Tim T Binnewies, Antonio G Pisabarro, David W Ussery, Juan M García-Lobo, and José A. Oguiza
TÍTULO: Differences in two-component signal transduction proteins among the Genus Brucella: implications for host preference and pathogenesis
REVISTA: Vet Microbiol. 174: 478-4832010
AUTORES : Viadas C, Rodríguez MC, García-Lobo JM, Sangari FJ, López-Goñi I
TÍTULO: Transcriptome analysis of the Brucella abortus BvrR/BvrS two-component regulatory system doi:10.1371/journal.pone.0010216
Revista: PLOS One . 5 : e20116. 2010
AUTORES: Seoane, A., F.J. Sangari and J.M. García Lobo
TÍTULO: Complete nucleotide sequence of the fosfomycin resistance transposon Tn2921
Revista: Int J Antimicrob Agents . 35: 413-4142010
AUTORES: Félix J Sangari, Ana M Cayon, Asuncion Seoane and Juan M Garcia-Lobo
TÍTULO: Brucella abortus ure2 region contains an acid-activated urea transporter and a nickel transport system.
REVISTA: BMC Microbiol. 10:107. 2010
AUTORES: Fernández-González E, de Paz HD, Alperi A, Agúndez L, Faustmann M, Sangari FJ,
Dehio C, Llosa M.
TÍTULO: Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells
REVISTA: J Bacteriol. 193:6257-65. 2011.
AUTORES: García-Lobo JM Rodríguez MC,Seoane A, Sangari FJ, López-Goñi I.
TITULO: The exploration of Brucella transcriptome: From the ORFeome to RNAseq
REVISTA/LIBRO: Lopez Goñi and O’Callaghan eds. Brucella. Molecular Microbiology and Genomics. pp 89-102. Caister Academic Press. Norfolk, UK, 2012
Contact:
Dr. Juan M. García Lobo
Phone: (+34) 942 201948 / Fax : (+34) 942 266399
Email: jmglobo@unican.es
Mailing address: IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander
