MECHANISMS AND REGULATION OF CELL DIVISION
IP: Alberto Sánchez Díaz, Investigador Ramón y Cajal
Other personnel:
Web page:
http://grupos.unican.es/bmcancer/celldivision/
Research interests:
- Molecular details of Inn1 function during cell division in budding yeast and how Inn1 is recruited to the cleavage site.
- How Cyclin Dependent Kinase (CDK) and the Mitotic Exit Network (MEN) regulate cell division in budding yeast cells.
Funding:
Publications:
Nkosi, P., Targosz, B., Labib, K., and Sanchez-Diaz, A. Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast. .Plos One 8 (2): e57846 (2013).
Devrekanli, A., Foltman, M., Roncero, C., Sanchez-Diaz, A. and Labib K. Inn1 and Cyk3 regulate the catalytic domain of chitin synthase during cytokinesis in budding yeasts. J. Cell Sci. 125, 5453-5466 (2012).
Sanchez-Diaz, A., Nkosi, P., Murray, S. and Labib, K. The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth. EMBO J., 31, 3620-3634 (2012).
van Deursen F, Sengupta S, De Piccoli G, Sanchez-Diaz A., Labib K. Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J., 31, 2195-2206 (2012).
Sanchez-Diaz, A., Marchesi, V., Murray, S., Jones, R., Pereira, G., Edmondson, R., Allen, T. and Labib K. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat Cell Biol. 10, 395-406 (2008).
Gambus A, Jones RC*, Sanchez-Diaz A.*, Kanemaki M, van Deursen F, Edmondson R and Labib K. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol. 8, 358-66 (2006).
Sanchez-Diaz, A.*, Kanemaki, M.*, Marchesi, V. and Labib, K. Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron. Sci. STKE 2004, pl8 (2004).
Kanemaki, M.*, Sanchez-Diaz, A.*, Gambus, A. and Labib, K. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature 423,720-4 (2003).
Sanchez-Diaz, A.*, Blanco, M.*, Jones, N. and Moreno, S. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. Current Genetics 40, 110-8 (2001).
Blanco, M.*, Sanchez-Diaz, A.*, de Prada, J.M. and Moreno, S. APC(ste9/srw1) promotes degradation of mitotic cyclins in G1 and is inhibited by cdc2 phosphorylation. EMBO J. 19, 3945-55 (2000).
Sanchez-Diaz, A., Arellano, M., Gonzalez, I. and Moreno, S. The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast. J Cell Sci. 111, 843-51 (1998).
Sanchez-Diaz, A., Ruano, M.J., Lorente F. and Hueso P. A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas. J Pediatr Gastroenterol Nutr. 24, 405-10 (1997).
Contact:
Dr. Alberto Sánchez Díaz
Phone: (+34) 942 201569 / Fax : (+34) 942 266399
Email: a.sanchezdiaz@unican.es
Mailing address: IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander
