Tema de investigación:

          Genética de poblaciones de enfermedades complejas (Esquizofrenia, Diabetes, Obesidad, Osteoporosis)

Financiación:

          Ministerio de Educación 2011-2014

          The Children's Hospital of Philadelphia - Research Institute 2012-2014 

Publicaciones relevantes (últimos 10 años) 

• Bolado-Carrancio A, Riancho JA, Sainz J, Rodríguez-Rey JC. (2014) Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells. Biochemical and Biophysical Research Communications (in press)
• Ayesa-Arriola R, Roiz-Santiañez R, Pérez-Iglesias R, Ferro A, Sainz J, Crespo-facorro B (2013). Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit a 3-year longitudinal study. Front. Psychiatry. 4: 134
• Delgado-Calle J, Fernández AF, Sainz J, Zarrabeitia MT, Sañudo C, García-Renedo R, Pérez-Núñez MI, García-Ibarbia C, Fraga MF, Riancho JA. (2013) Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum. 65:197-205.
• Sainz J, Mata I, Barrera J, Perez-Iglesias R, Varela I, Arranz MJ, Rodriguez MC, Crespo-Facorro B. (2013) Inflammatory and immune response genes have significantly altered expression in schizophrenia. Molecular Psychiatry. Oct;18(10):1056-7.
• Sainz J. (2012) A methodology to identify and prioritize gene candidates for human disease. Front Genet. 3:133. Epub 2012 Jul 18
• Zarrabeitia MT, Valero C, Martín-Escudero JC, Olmos JM, Bolado-Carrancio A, de Sande-Nacarino EL, Rodríguez-Rey JC, Sainz J, Riancho JA. (2012) Association study of sirtuin 1 polymorphisms with bone mineral density and body mass index. Arch Med Res. 43:363-8.
• Riancho JA, Liu Y, Sainz J, García-Pérez MA, Olmos JM, Bolado-Carrancio A, Valero C, Pérez-López J, Cano A, Yang T, Sañudo C, Deng HW, Rodríguez-Rey JC. Nuclear receptor NR5A2 and bone: gene expression and association with bone mineral density. (2012) Eur J Endocrinol. 166:69-75.
• Riancho JA, Vázquez L, García-Pérez MA, Sainz J, Olmos JM, Hernández JL, Pérez-López J, Amado JA, Zarrabeitia MT, Cano A, Rodríguez-Rey JC. Association of ACACB polymorphisms with obesity and diabetes (2011). Mol Genet Metab. 104:670-6.
• Sanchez-Juan P, Bishop MT, Aulchenko YS, Brandel JP, Rivadeneira F, Struchalin M, Lambert JC, Amouyel P, Combarros O, Sainz J, Carracedo A, Uitterlinden AG, Hofman A, Zerr I, Kretzschmar HA, Laplanche JL, Knight RS, Will RG, van Duijn CM (2011) Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk. Neurobiol Aging. Nov 30 [Epub ahead of print]
• Deardorff MA, Sainz J, Grant SF (2011). Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion. BMC Med. 3:9-13.
• Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Cazier JB, Sainz J, Jakobsdottir M, Kostic J, Magnusdottir DN, Ghosh S, Agnarsson K, Birgisdottir B, Le Roux L, Olafsdottir A, Blondal T, Andresdottir M, Gretarsdottir OS, Bergthorsson JT, Gudbjartsson D, Gylfason A, Thorleifsson G, Manolescu A, Kristjansson K, Geirsson G, Isaksson H, Douglas J, Johansson JE, Balter K, Wiklund F, Montie JE, Yu X, Suarez BK, Ober C, Cooney KA, Gronberg H, Catalona WJ, Einarsson GV, Barkardottir RB, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K (2006) A common variant associated with prostate cancer in European and African populations. Nature Genetics 38:652-8.
• S F.A. Grant, G Thorleifsson, I Reynisdottir, R Benediktsson, A Manolescu, J Sainz, A Helgason, H Stefansson, V Emilsson, A Helgadottir, U Styrkarsdottir, G. B Walters, E Palsdottir, T Jonsdottir, T Gudmundsdottir, A Gylfason, J Saemundsdottir, M P. Reilly, D J. Rader, Y Bagger, C Christiansen, V Gudnason, G Sigurdsson, U Thorsteinsdottir, J R. Gulcher, A Kong, K Stefansson (2006) Variant of the transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics  38:320-3.
• A Helgadottir, A Manolescu, A Helgason, G Thorleifsson, U Thorsteinsdottir, D Gudbjartsson, S Grant, J Sainz, SJ O’Brien, SE Matthiasson, AI Levey, JL Abramson, M Reilly, V Vaccarino, M Wolfe, V Gudnason, AA Quyyumi, EJ Topol, DJ Rader, G Thorgeirsson, JR Gulcher, H Hakonarson, A Kong, K StefanssoN (2006) A variant of the gene encoding leukotriene A4 hydrolase confers ethnic specific risk of myocardial infarction. Nature Genetics  38:68-74.

Contacto:

Dr. Jesús Sainz

Teléfono: (+34) 942 201577 / Fax : (+34) 942 266399

Correo electrónco: sainzjv@unican.es

Dirección postal: IBBTEC. C/ Albert Einstein 22, PCTCAN, 39011 Santander